- Designed, implemented, and optimized quantitative multimodal optical imaging platform for studying the neurovascular hemodynamics of ischemic stroke.
- Rapid development of clinical laser speckle contrast imaging (LSCI) system for intraoperative blood flow monitoring during neurosurgery.
- Modernized multi-exposure speckle imaging (MESI) optical system
- Development of custom software (Qt C++) for real-time LSCI acquisition, processing, and visualization.
- Development of numerical Monte Carlo model of dynamic light scattering for computational speckle contrast optical tomography in the brain.
- Laser speckle contrast imaging for visualizing blood flow during cerebral aneurysm surgery: A comparison with indocyanine green angiography (Under Review)
- Visualizing anesthesia-induced vasodilation of cerebral vasculature using multi-exposure speckle imaging (Under Review, bioRxiv Preprint)
- Establishing the effect of vascular structure on laser speckle contrast imaging (Under Review, bioRxiv Preprint)
- Peripheral electrical stimulation augments cerebral collateral circulation if performed within a critical time window. (bioRxiv Preprint)
- Multimodal mapping of neural activity and cerebral blood flow reveals long-lasting neurovascular dissociations after small-scale strokes (Science Advances, 2020)
- Rehabilitative training interacts with ischemia-instigated spine dynamics to promote a lasting population of new synapses in peri-infarct motor cortex (Journal of Neuroscience, 2019)
- Artery targeted photothrombosis widens the vascular penumbra, instigates peri-infarct neovascularization and models forelimb impairments (Scientific Reports, 2019)
- Imaging of cortical oxygen tension and blood flow following targeted photothrombotic stroke (Neurophotonics, 2018)
- Nanoelectronics enabled chronic multimodal neural platform in a mouse ischemic model (Journal of Neuroscience Methods, 2018)
- In vivo multiphoton imaging of a diverse array of fluorophores to investigate deep neurovascular structure (Biomedical Optics Express, 2017)
Posters / Presentations
- Longitudinal multimodal mapping of neural activity and blood flow reveals neurovascular dissociations in an awake mouse model of microinfarcts (Neural Imaging and Sensing 2020)
- Computational speckle contrast optical tomography (SPIE BiOS 2019)
- A fast three-dimensional dynamic light scattering computational model for imaging through turbid media (Advances in Optics for Biotechnology, Medicine and Surgery XVI 2019)
- Targeted photothrombotic stroke: a method for producing upper extremity impairments in mice (Neuroscience 2016)
- Enlarging the penumbra with a slight variation of the standard photothrombotic technique: targeted artery occlusion (Neuroscience 2016)
- Simultaneous imaging of oxygen tension and blood flow during stroke using a digital micromirror device (Austin Translational Neuroscience Symposium 2014)
- Simultaneous imaging of oxygen tension and blood flow during stroke using a digital micromirror device (BMES 2014)
- Delivery of oxygen-sensitive two-photon contrast agent to the mouse brain via blood brain barrier disruption using ultrasound and microbubbles (BMES 2013)
Project: Development of a novel protein-based force sensor for use in detecting and measuring tensile mechanical forces related to cellular adhesion. Focused on the design of an in vitro testing system to selectively apply forces to the chimeric fluorogen-activating protein and visualize the resulting changes in fluorescent signal.
Poster: Demonstrating functionality of fluorogen-activating protein force sensor (Undergraduate Research Symposium 2011)
Advisor: Ming Luo, Ph.D. (Center for Biophysical Sciences and Engineering)
Project: Developed protocol for the isolation and chromatographic purification of recombinant Ebola virus nucleocapsid protein for characterization with electron microscopy and RNA extraction.